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What is the “slow” caffeine metabolizer variant?

The “slow” genetic variant is associated with lower levels of the CYP1A2 enzyme and a slower rate of caffeine breakdown. People who inherit the “slow” variant take longer to clear caffeine from their body.

The longer the caffeine stays in circulation, the higher the risk of heart problems and hypertension. Reduced caffeine consumption is recommended for “slow” metabolizers.

 

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